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RAPHAS

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Technology

Dissolving Microneedles

What Are Dissolving Microneedles?

Dissolving microneedles represent an innovative transdermal Drug Delivery System (DDS) utilizing hyaluronic acid, a natural moisturizing substance found within the human body.

By combining active ingredients with a hyaluronic acid backbone, these microneedles are precisely molded to one-third the thickness of a human hair. Upon penetrating the skin, they react with internal moisture and dissolve, efficiently delivering essential compounds deep into the dermal layers.

Unlike conventional injectables, this microneedle technology is garnering widespread attention as a next-generation solution that is easy to store at room temperature, requires no medical professionals for application, and delivers highly effective, pain-free results. In the cosmetics industry, it is making waves as a breakthrough technology that overcomes the limitations of traditional topical products hindered by the skin barrier.

Characteristics of Microneedle Technology
Depth of Absorption · Speed of Absorption
258.750UP
%
Application of Conventional Essence
  • 1 Hour After Application
Application of Microcone Patch
  • 1 Hour After Application
  • 2.6 Times Higher Absorption Rate

The images above visually compare the absorption rates when the exact same active ingredients are applied to the skin in a conventional essence format versus a microneedle format.

The red areas indicate the degree of active ingredient absorption. A side-by-side comparison clearly demonstrates that the active ingredients are delivered far more effectively deep into the skin when utilizing the microneedle patch.

Raphas' dissolving microneedles deliver an exceptional absorption rate of 258.750% compared to conventional essences formulated with identical ingredients.
A single application of our patch yields the exact same remarkable efficacy as 10 applications of a standard essence product.

3D Visualization of Ingredient Release from Microcones Using a Confocal Laser Scanning Microscope
  • Aqueous solution immediately after application
    Immediately After
    Aqueous Solution
    Microneedle immediately after application
    Immediately After
    Microneedle Application
  • Aqueous solution 3 hours later
    3 Hours Later
    Aqueous Solution
    Microneedle 3 hours later
    3 Hours Later
    Microneedle Application
  • 3D Image from an Altered Angle
    3D Image from an Altered Angle
Confirmed as an exceptional dissolving device where microcones rapidly deliver and broadly diffuse active ingredients deep into the skin (Utilizing HA + Rhodamine B).
Formulations encapsulating ingredients within microcones exhibit a significant difference in diffusivity compared to standard aqueous solutions that are merely applied topically.